As a substantial public health crisis, obesity – and its host of comorbid cardiometabolic conditions – continues to demand improved prevention efforts and treatment methods to deter its rapidly increasing prevalence. While rates of obesity continue to rise and patients increasingly suffer from diabetes, cardiovascular disease, and other related health complications, ongoing growth within the field of obesity research aims to uncover efficacious therapies to combat this epidemic.
The prevalence of obesity in the American population shows few signs of regression, which increasingly draws concern for younger demographics. Obesity is the most common nutritional disorder affecting younger age groups with approximately 21-24% overweight and 16-18% obese children and adolescents. The complexity and multifactorial nature of the disorder make treatment strategies difficult; long-term complications associated with childhood obesity emphasize the need for improved efforts in prevention and condition management. Obese children and adolescents are predisposed to insulin resistance, type 2 diabetes, hypertension, hyperlipidemia, liver and renal disease, as well as reproductive dysfunction and face an increased risk of adult-onset obesity and cardiovascular disease.