June 10th, 2021 celebrates International NASH Day which is part of an ongoing effort supported by CMHC partner, the Global Liver Institute to spread awareness of nonalcoholic steatohepatitis (NASH), the advanced form of nonalcoholic fatty liver disease (NAFLD), as well as actions to address the condition. Currently, the global burden of NAFLD is estimated at a worldwide prevalence of 11%, representing nearly 900 million cases, and has demonstrated a 33% increase over the course of the past 30 years.

Although many patients may experience buildup of fat in the liver without symptoms or health repercussions, in some cases excess fat contributes to inflammation and damage to liver cells even causing cirrhosis. Without appropriate treatment or management, such cases can lead to the development of NAFLD and consequently, to nonalcoholic steatohepatitis. As this condition is an advanced form of disease, it is increasingly important to pinpoint intervention targets and develop effective treatment methods to halt its progression.

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