International NASH Day: New Antibodies Discovered Play Significant Role in NAFLD

June 10th, 2021 celebrates International NASH Day which is part of an ongoing effort supported by CMHC partner, the Global Liver Institute to spread awareness of nonalcoholic steatohepatitis (NASH), the advanced form of nonalcoholic fatty liver disease (NAFLD), as well as actions to address the condition. Currently, the global burden of NAFLD is estimated at a worldwide prevalence of 11%, representing nearly 900 million cases, and has demonstrated a 33% increase over the course of the past 30 years.

Although many patients may experience buildup of fat in the liver without symptoms or health repercussions, in some cases excess fat contributes to inflammation and damage to liver cells even causing cirrhosis. Without appropriate treatment or management, such cases can lead to the development of NAFLD and consequently, to nonalcoholic steatohepatitis. As this condition is an advanced form of disease, it is increasingly important to pinpoint intervention targets and develop effective treatment methods to halt its progression.

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Ideal Cardiovascular Health Behaviors and NAFLD Prevalence

As a very common disorder, nonalcoholic fatty liver disease (NAFLD) is considered a significant risk factor for cardiovascular disease and a threat to cardiometabolic health. A series of ideal cardiovascular behaviors can be implemented as a prevention strategy to mitigate potential disease development. According to Ebenezer Oni, MD, MPH, cardiologist of the division of cardiology at the Heart and Vascular Institute at Albert Einstein Medical Center, Philadelphia, and his colleagues, “NAFLD is strongly linked to insulin resistance, obesity and metabolic syndrome; all of which are associated with cardiovascular disease.”

A recent study  published in late 2020 in The American Journal of Medicine evaluated the prevalence of NAFLD in participants who were assessed using the American Heart Association’s Life’s Simple 7 cardiovascular behavior recommendations.  Read more