In many cases, hypertriglyceridemia is multifactorial, resulting from a combination of genetic factors and other causes of increased triglyceride-rich lipoprotein production. It can also stem from a high calorie diet or uncontrolled diabetes – both risk factors affect a significant portion of the U.S. population today. Suffering from high triglyceride levels raises the risk of cardiometabolic conditions, including heart disease, stroke and diabetic neuropathy; it has also been linked to pancreatitis and fatty liver disease. Despite the known long-term complications, most cases of severe hypertriglyceridemia result from uncontrolled type 2 diabetes caused by a lack of routine monitoring after initial elevated triglyceride measurement.

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