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CMHC PULSE

Cardio Metabolic Health Congress – Official Blog

Pregnancy-Related Cardiovascular Risk Tied to BMI and Blood Pressure

Women who have experienced hypertensive disorders of pregnancy (HDP) face a doubled risk of cardiovascular disease compared with those who have had normotensive pregnancies – and their risk factor levels remain higher through age 50 and beyond. Hypertensive disorders of pregnancy and cardiovascular disease share a host of common modifiable risk factors including adiposity, hypertension, hyperglycemia, and dyslipidemia. Although it is not known how much of the excess pregnancy-related CVD risk is associated with these elevated risk factors, they may be an important target for prevention in women with a history of HDP.

While previous studies have quantified the increased risk women for with HDP, prior research aims to estimate the proportion of conventional cardiovascular risk factors associated with elevated CVD risk. A 2019 prospective cohort study of pregnant women found that 77% of excess cardiovascular risk for women with a history of hypertensive disorders of pregnancy is attributed to elevated blood pressure and BMI levels.

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Association of Cigarette and E-Cigarette Use with CVD Biomarkers 

Although the prevalence of cigarette smoking has significantly declined from nearly 21% of the U.S. adult population identifying as smokers in 2005 to only 14% today, an estimated 34.1 million adults still currently smoke cigarettes. In addition, many have transitioned to the use of electronic cigarettes in hopes of reducing cardiometabolic risks. However, the cardiovascular toxicity of electronic cigarettes is not well understood and comprehensive population data assessing their adverse effects remains sparse.

Researchers continue to investigate the repercussions of both cigarette and e-cigarette use, including the specific cardiovascular disease biomarkers that can act as predictive factors for CVD events. Inflammation and oxidative stress have been identified as key contributors of smoking-induced cardiovascular disease prompting scientists to evaluate these measures in current smokers. Findings recently published in Circulation reveal that similar levels of inflammation and oxidative stress biomarkers can be observed in patients who use both electronic cigarettes and cigarettes and those who exclusively smoke cigarettes.

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