Cardio Metabolic Health Congress – Official Blog

PCSK9 Inhibitors May Benefit Patients with Acute Coronary Syndrome

Results of a recent study published in the Annals of Internal Medicineshowed that patients with acute coronary syndrome (ACS) who were treated with PCSK9 inhibitors benefited not only from LDL-cholesterol reduction but plaque stabilization as well. Currently, the PCSK9 inhibitors evolocumab and alirocumab are approved for lowering of LDL in patients with familial hypercholesterolemia or clinical atherosclerotic cardiovascular disease who are not at goal despite maximally tolerated statin therapy.

According to the study authors, acute coronary events result in a dynamic increase of PCSK9 levels that may have an effect on plaque vulnerability of both culprit and nonculprit coronary vessels, thus leading to a potential role for PCSK9 inhibitors in managing ACS. Further, formal study on the timing of PCSK9 inhibitor administration to patients with ACS and their effects on inflammatory and thrombosis pathways will be necessary. For more perspective on the study, read here.

To learn more on managing high-risk patients in the PCSK9 era, don’t miss the Best of the CMHC Regional Conference Series taking place in Atlanta, GA on May 7 and in Chicago, IL on June 18, as well as the 11th Annual CMHC in Boston, MA October 5- 8, 2016.

Navarese EP et al. Proprotein convertase subtilisin/kexin type 9 monoclonal antibodies for acute coronary syndrome: a narrative review. Ann Intern Med. Published online 22 March 2016 doi:10.7326/M15-2994.

Healio. PCSK9 inhibitors may be appropriate for use in patients with ACS.

GLP-1 Agonist Liraglutide Shown to Significantly Reduce the Risk of Major Adverse Cardiovascular Events in LEADER

Results of the cardiovascular outcomes LEADER trial have shown the GLP-1 agonist liraglutide to significantly reduce the risk of major adverse cardiovascular events. The trial, which began in 2010, included 9340 high-risk adults with type 2 diabetes who were randomized to either placebo or liraglutide along with standard treatment. The primary endpoint of LEADER was defined as the composite outcome of the first occurrence of cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke. The superior reduction of major adverse cardiovascular events demonstrated by liraglutide was derived from all three components of the endpoint.

Last year, the SGLT-2 inhibitor empagliflozin was the first glucose-lowering agent to demonstrate cardiovascular risk reduction in a CV outcomes trial. Other CV outcomes trials have shown neutral results with regard to cardiovascular risk reduction or have raised concern about a potentially increased risk for heart failure.

Full data from LEADER are expected to be presented at the American Diabetes Association’s Annual Scientific Sessions in June. For additional commentary on LEADER read more here.

Perspective on these results will also be shared by our expert faculty during “The Shifting Sands of CVD Prevention in Diabetes––A New Outlook for Patient Care,” during The Best of the CMHC Regional Conference Series, in Atlanta on May 7, 2016 and in Chicago on June 18, 2016, and at the 11th Annual CMHC in Boston, October 5-8, 2016.

Medscape. Top-line data show CV benefit for liraglutide in type 2 diabetes.