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CMHC PULSE

Cardio Metabolic Health Congress – Official Blog

Intravascular Ultrasound Insights into the Regression and Progression of Coronary Atherosclerosis

“The value of a technique, in part, is if it can show you what is likely to work and not likely to work,” according to Dr. Steven E. Nissen, Chairman, Department of Cardiovascular Medicine at the Cleveland Clinic. In his keynote presentation, Intravascular Ultrasound Insights into the Regression and Progression of Coronary Atherosclerosis, Dr. Nissen will discuss the role of IVUS as a screening tool and in determining new approaches to treatment and selecting those that are suitable for further development versus those that are not.

“What IVUS has taught us from the very beginning is that atherosclerosis is not a disease of the coronary lumen, it is a disease of the vessel wall,” he said. Dr. Nissen will describe the method behind IVUS and early findings associated with its use. About 10 randomized controlled trials have been done with IVUS to examine different approaches to either slow progression or induce regression of coronary atherosclerosis. Dr. Nissen will review some of these trials (eg, REVERSAL and ASTEROID) as well as discuss future directions (eg, the Apoa1 Milano project). Dr. Nissen will also touch on the ongoing GLAGOV trial, which is studying high-dose statin therapy alone compared with high-dose statin therapy plus a PCSK9 inhibitor, for which results are expected later this year.

Will New AACE Guidelines Help Obesity to be Taken More Seriously?

Updated guidelines strive for obesity to be treated as a chronic condition

The obesity epidemic shows no signs of slowing, with an estimated 640 million people worldwide now considered obese. According to the CDC, every 2 of 3 adults are overweight or obese. Recently, the American Association of Clinical Endocrinologists (AACE), who declared obesity a disease in 2012, released evidence-based management guidelines that recommend obesity be approached as a chronic medical condition. Their rationale for the update? “Obesity medicine lacks comprehensive and evidence-based guidelines that are translatable to real-world clinical care of patients with obesity,” said AACE Obesity Scientific Committee Chair W. Timothy Garvey, MD.
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