Category: GLP-1

GLP-1 Receptor Agonists and SGLT-2 Inhibitors: A Dynamic Duo?

September 23, 2016

First clinical trial to study GLP-1 receptor agonist and SGLT-2 inhibitor combination shows positive results

Experts have speculated that combination GLP-1 receptor agonist and SGLT-2 inhibitor therapy may have synergistic, beneficial effects in the treatment of type 2 diabetes. Now there are data to support this, as results of DURATION-8, the first clinical trial to study the combination as an addition to standard-of-care therapy, were recently announced at the European Association for the Study of Diabetes (EASD) 2016 Annual Meeting and published in the Lancet Diabetes and Endocrinology. Read more

Another GLP-1 Agonist, Semaglutide, Shows Cardiovascular Benefit in CV Outcomes Trial SUSTAIN 6

The GLP-1 agonist semaglutide is the latest diabetes therapy to show cardiovascular benefit in a CV outcomes trial, demonstrating a reduction in the risk of major adverse cardiovascular events compared with usual care.

SUSTAIN 6 included 3,297 patients with type 2 diabetes on a standard diabetes care regimen randomized to once-weekly semaglutide or placebo for 2.1 years. Among those who received semaglutide, the rate of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke was lowered to 6.6% compared with 8.9% in the placebo group receiving usual care. Researcher Dr. Steven Marso of HCA Midwest Health Research Medical Center in Kansas City, MO, commented that this lower risk was largely driven by a significant (39%) decrease in the rate of nonfatal stroke and a nonsignificant (26%) decrease in nonfatal myocardial infarction. No significant difference in the rate of cardiovascular death was observed. Read more