In many cases, hypertriglyceridemia is multifactorial, resulting from a combination of genetic factors and other causes of increased triglyceride-rich lipoprotein production. It can also stem from a high calorie diet or uncontrolled diabetes – both risk factors affect a significant portion of the U.S. population today. Suffering from high triglyceride levels raises the risk of cardiometabolic conditions, including heart disease, stroke and diabetic neuropathy; it has also been linked to pancreatitis and fatty liver disease. Despite the known long-term complications, most cases of severe hypertriglyceridemia result from uncontrolled type 2 diabetes caused by a lack of routine monitoring after initial elevated triglyceride measurement.
Around $1.3 billion of gross domestic product is allotted to diabetes care globally, according to research from the University of Göttingen and Harvard T.H. Chan School of Public Health. The substantial economic burden of the condition continues to grow, with the average annual cost of care in the U.S. rising 13% between 2012 and 2017. Current analysis of the high expenditure and prevalence suggests the need for policies and programs that prevent and treat diabetes. Improved treatment strategies could lead to notable economic benefits and the redirection of scarce health care resources towards other areas of need.