Category: Type 2 Diabetes

Elevated Blood Pressure Increases Risk of Type 2 Diabetes

Results of a recent study published in the Journal of the American College of Cardiology are lending weight to the widely believed hypothesis that hypertension is an independent risk factor for type 2 diabetes. The study, an analysis of electronic health records and a meta-analysis, consisted of 4.1 million adults without diabetes and cardiovascular disease. The objective was to evaluate the association between usual blood pressure and risk of diabetes.

Each 20 mmHg increase in systolic blood pressure and 10 mmHg increase in diastolic blood pressure was associated with a 58% and a 52% higher risk of new-onset diabetes. The strength of that association per 20 mmHg higher SBP decreased with age and increasing body mass index. According to the study authors, “Elevated blood pressure is associated with chronic inflammation and endothelial dysfunction, both of which appear to be mediators of diabetes risk. There is, therefore, a biological rationale to suspect that elevated blood pressure may cause new-onset diabetes.” Read more

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AHA/ADA Updates Scientific Statement on CVD Prevention for Patients with Type 2 Diabetes

In an update to their previous 2007 statement, the AHA and ADA recently presented a review of the current literature and key clinical trials regarding blood pressure and glucose control, cholesterol management, aspirin therapy, and lifestyle modification for primary prevention of CVD in patients with type 2 diabetes. Both the AHA and ADA believed an update was in order due to the major changes that have occurred in the past several years in each of the “ABC” elements of diabetes care (HbA1c, blood pressure, and cholesterol), and because CVD remains the leading cause of death among patients with type 2 diabetes. Read more

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Diabetes Management Update

What is the link between diabetes and Alzheimer’s disease? C. Ronald Kahn, MD will present “Is Alzheimer’s Disease Type 3 Diabetes?” Dr. Kahn will discuss the correlation between the two, the effect of insulin resistance on brain function, and the potential use of antidiabetic medications in Alzheimer’s disease and dementia.

With regard to novel diabetes therapies, according to John B. Buse, MD, PhD, “I suspect that the combination of GLP-1 receptor agonists and basal insulin will become the default pathway of diabetes management in the future; and SGLT-2 inhibitors, as a once-daily oral medication, are compelled to play a central role in diabetes care moving forward.” Dr. Buse will discuss these points further in Type 2 Diabetes Management 2014, followed by Howard Wolpert, MD who will discuss the physiologic and practical considerations of initiating insulin therapy and avoiding the extremes of hyper- and hypoglycemia. Read more

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