Month: May 2016

Insulin Degludec/Liraglutide 1 Step Closer to US FDA Approval

An FDA advisory committee has voted unanimously in favor of approval of the combination type 2 diabetes treatment insulin degludec/liraglutide. The panel also agreed that the combination treatment would at least be appropriate for patients who had previously used an insulin analogue or GLP-1 agonist, but no other consensus was reached regarding which patient types would be suitable candidates. Members of the advisory committee indicated the combination treatment was needed and expressed hope an insulin-containing combination might overcome “insulin inertia” among clinicians.

Medscape Medical News. FDA panel backs Novo Nordisk Insulin-GLP-1 Combination IDegLira. May 25, 2016.

ACCF/AHA Guideline for the Management of Heart Failure Updated in Light of New Treatment Options

An update to the 2013 ACCF/AHA Guideline for the Management of Heart Failure was recently released to reflect the addition of two new pharmacotherapeutic options in the treatment of heart failure: valsartan/sacubitril, an angiotensin receptor-neprilysin inhibitor (ARNI) and ivabradine, a sinoatrial node modulator. The update clarifies that patients with chronic symptomatic HF with reduced ejection fraction should be given a regimen consisting of an ACE inhibitor or ARB or ARNI along with a beta blocker and an aldosterone antagonist. ARNIs should replace ACE inhibitors or ARBs when stable patients with mild-to-moderate HF on those therapies have an adequate blood pressure and are otherwise tolerating standard therapies well. According to Clyde W. Yancy, MD, MSc, MACC, who chaired the writing committee, “Not every patient is a good candidate for every drug; these guidelines can help physicians decide who best fits which treatment. This document details the benefits and risks of these new therapies so that patients at high risk can be directed towards alternative therapies.”

American College of Cardiology. Societies release focused update for HF management. May 20, 2016.

2016 ACC/AHA/HFSA Focused Update on New Pharmacological Therapy for Heart Failure: an Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure. J Am Coll Cardiol. 2016; doi:10.1016/j.jacc.2016.05.011.